Immunoglobulin-production and surface-bound immunoglobulins in chronic lymphocytic leukemia, lymphosarcoma, and so-called reticulum cell sarcoma.

Conventional light and electron microscopic methods do not allow a differentiation of Tand B-cells. A clasdficntion of neoplastic lymphatic cells into one of these subpopulations is therefore impossible with common morphological methods. It was not until specific cell funktions, i e. immunoglobulin(IG)-production and the formation of surface-Ig(S-Ig)-receptors, were demonstrable that one could identify B-cells and thereby distinguish them from T-cells. The demonstration of Ig-production therefore represents a method which reveals more information about the nature of mdignant lymphoma cells,